Mancozeb, the last fungicide to be withdrawn in the EU

On 23 October, the European Commission authorised the non-renewal of the fungicide mancozeb. Its marketing will be allowed until January 2021, with a transition period of 1 year (agrodigital, 2020). Mancozeb [[1,2-ethanediylbis] carbamodithioate]] (2-)] is a mixture of manganese with [[1,2-ethanediylbis [carbamodithioate]] (2-) zinc belonging to the group of dithiocarbamate fungicides and more specifically to the class of compounds known as ethylene bisdithiocarbamates (EBDC). This group of compounds also includes active substances close to mancozeb such as: maneb, metiram, propineb and zineb. Mancozeb is classified by the Fungicide Resistance Action Committee (FRAC) in mode of action group M (Multi-site action). Mancozeb itself is not fungicidal and can effectively be considered a pro-fungicide, which when exposed to water, decomposes to release ethylene bisisothiocyanate sulphide (EBIS), which is then converted by the action of ultraviolet light to ethylene bisisothiocyanate (EBI). EBIS and EBI are active toxic agents, which interfere with enzymes containing sulphydryl groups. Disruption of these central enzymatic processes inhibits or interferes with at least six different biochemical processes within the fungal cell cytoplasm and mitochondria leading to pathogen death (Gullino, et al. 2010). In Europe, the main consumers of this type of fungicides (dithiocarbamates) are France, Italy and Spain accounting for almost 62% of the total consumed and 9.8% of the total consumption of fungicides and bactericides in 2017. Consumption of dithiocarbamate fungicides in the European Union (FAOSTAT, 2017) Governments around the world are limiting the use of agrochemicals, mainly due to their impact on health and the environment. An example of this is the new strategy recently published by the Commission called "from farm to fork" where it proposes reducing the use and risk of chemical pesticides by 50% and reducing the use of the most hazardous pesticides by 50% by 2030. The search for tools that allow disease-free crops, avoiding yield losses, environmentally friendly and respectful of public health, is an imminent need. TRICHODEX aware of this, is putting all its efforts and dedication into obtaining efficient solutions, which constitute an alternative to the use of this type of active material.


  • Gullino, M. L., Tinivella, F., Garibaldi, A., Kemmitt, G. M., Bacci, L., & Sheppard, B. (2010). Mancozeb: past, present, and future. Plant Disease, 94(9), 1076-1087.
  • Agrodigital, 2020 
  • FAOSTAT, 2017 

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